{"product_id":"abcam-ab165538","title":"Abcam, ab165538, Recombinant Human MGAT5B protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human MGAT5B protein is a Human Fragment protein, in the 1 to 394 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q3V5L5,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMGAT5B also known as beta-16-N-acetylglucosaminyltransferase 5B is an enzyme involved in glycosylation. This enzyme participates in the addition of N-acetylglucosamine to the core oligosaccharide of N-linked glycoproteins. MGAT5B has a mass of around 77 kDa. Expression of MGAT5B occurs mainly in the liver pancreas and certain tumor cells where it contributes to the creation of complex branched N-glycans. These glycan structures are important in modulating various cellular interactions and functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBranching of N-glycans by MGAT5B influences cell signaling and cell adhesion. It plays a role in enhancing the motility and invasiveness of tumor cells where it contributes to cellular communication and profile changes. MGAT5B localizes to the Golgi apparatus where it acts as part of the N-glycan biosynthetic pathway but does not appear to form a stable complex with other enzymes. Its actions support processes that require flexible and functional cell membranes.\u003cbr\u003e\nPathways\u003cbr\u003e\nMGAT5B participates in the N-glycan biosynthesis and the TGF-beta signaling pathway. Its actions leading to increased branches on N-glycans can enhance signaling pathways that regulate cell proliferation and differentiation. Related proteins such as TGF-beta interact with MGAT5B's products where branched glycans enhance the availability of receptors on the cell surface influencing the downstream signaling cascade.\u003cbr\u003e\nMGAT5B has significant implications in cancer and diabetes. In cancer the overexpression of MGAT5B stabilizes cell surface receptor availability leading to heightened migratory and invasive capabilities especially related to proteins like TGF-beta which can contribute to metastasis. In diabetes alterations in glycosylation patterns due to MGAT5B's action can impact insulin receptor signaling with potential impacts observed through interaction with proteins like the insulin receptor itself.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843916910761,"sku":"ab165538","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab165538","provider":"Iright","version":"1.0","type":"link"}