{"product_id":"abcam-ab166249","title":"Abcam, ab166249, Recombinant Human RAB7B protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human RAB7B protein is a Human Full Length protein, in the 1 to 199 aa range, expressed in Wheat germ, suitable for ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q96AH8,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRAB7B also known as Ras-related protein Rab-7b is a small GTPase belonging to the Ras superfamily. This protein weighs approximately 23 kDa. Researchers find RAB7B in various tissues including the immune and the central nervous system. It plays a direct role in intracellular protein trafficking and vesicular transport moving proteins and other molecules from one organelle to another within cells. Through its association with specific membrane compartments RAB7B assists in maintaining the dynamic balance of vesicle budding transport and fusion regulating endosomal sorting.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe functions of RAB7B include its contribution to lysosomal biogenesis and endosome-to-lysosome trafficking. It is part of a complex known as the endosomal transport modulation machinery where it interacts with multiple effector proteins to translocate cargo to the lysosome for degradation or recycling. In immune cells RAB7B helps modulate immune response by controlling the degradation of signaling receptors. This function makes it essential for cellular homeostasis and adaptive immune responses influencing antigen processing.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe interaction of RAB7B with other members of the Rab GTPase family situates it in important cellular pathways like the endocytic pathway and autophagy. In the endocytic pathway it coordinates with proteins like RAB5A transitioning early endosomes to late endosomes. The action in autophagy involves interaction with other autophagic regulators to aid in autophagosomal-lysosomal fusion influencing how cells handle stress and remove damaged components.\u003cbr\u003e\nAbnormal RAB7B expression has been linked to neurodegenerative diseases like Alzheimer's and immune disorders such as rheumatoid arthritis. Its interaction with other proteins like LRRK2 in Parkinson's disease implicates it in pathways that lead to neuronal damage and inflammation. In rheumatoid arthritis RAB7B influences immune cell signaling and cytokine release contributing to autoimmune responses. Understanding its associations aids in developing therapeutic strategies targeting the molecular functions of RAB7B in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843962065065,"sku":"ab166249","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab166249","provider":"Iright","version":"1.0","type":"link"}