{"product_id":"abcam-ab16662","title":"Abcam, ab16662, Anti-ErbB2 \/ HER2 antibody [SP3]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 500µL \/ 1mL\u003cbr\u003e\nAnti-ErbB2 \/ HER2 antibody [SP3] (ab16662) is a rabbit monoclonal antibody detecting ErbB2 \/ HER2 in  IHC-P . Suitable for  Human . - Biophysical QC for unrivalled batch-batch consistency - Trusted since 2005\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:SP3,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nEpitope:Extracellular domain,\u003cbr\u003e\nSpecificity:This antibody has some non-specific staining signals in skeletal muscle tissues in IHC-P. For better sensitivity and less background, we recommend ab134182 and ab237715 as alternatives.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was switched from a hybridoma to recombinant production method on 5th March 2019.\u003cbr\u003e\nProduct Specifications\u003cbr\u003e\nAnti-ErbB2 \/ HER2 antibody [SP3] (ab16662) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IHC-P in human samples.\u003cbr\u003e\nAnti-ErbB2 \/ HER2 antibody [SP3] (ab16662) specifically detects ErbB2 \/ HER2 (UniProt ID: P04626; Molecular weight: 136kDa) and is sold in 100 µL, 500 µL and 1 mL selling sizes.\u003cbr\u003e\nAnti-ErbB2 \/ HER2 antibody [SP3] (ab16662) is a clone from the portfolio of Spring Bioscience (Roche) SP clones which have been optimised for immunohistochemistry (IHC).\u003cbr\u003e\nQuality and Validation\u003cbr\u003e\nAbcam's high quality manufacturing and validation processes ensure Anti-ErbB2 \/ HER2 antibody [SP3] (ab16662) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.\u003cbr\u003e\nRelated Products\u003cbr\u003e\nAntibody clone SP3 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647 (\u003cbr\u003e\nab270190\u003cbr\u003e\nab270191\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.1% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe ErbB2 also known as HER2 or HER2 protein is a transmembrane receptor protein with a molecular weight of about 185 kDa. It serves as part of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. The ErbB2 protein is expressed mainly in epithelial tissues including those of the breast and the gastrointestinal tract. It lacks a known ligand-binding domain which sets it apart from other members of its family. Due to its structure ErbB2 dimerizes with other members of the EGFR family to exert its effects in cellular signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of ErbB2 extends beyond a singular function. It becomes an active component when forming heterodimers with other EGFR family members such as ErbB3 to initiate various downstream signaling cascades. The dimerization activates intracellular pathways leading to cell proliferation survival differentiation and migration. Within cells ErbB2 influences processes critical for normal development and tissue homeostasis contributing significantly to signal transduction networks.\u003cbr\u003e\nPathways\u003cbr\u003e\nErbB2 plays a pivotal role in pathways such as the PI3K\/Akt and MAPK\/ERK pathways. These pathways are important in mediating cellular responses to growth signals. The PI3K\/Akt pathway activated by HER2 signaling regulates cell growth and survival while the MAPK\/ERK pathway contributes to cell differentiation and proliferation. ErbB2's interaction with proteins like ErbB3 is fundamental in these pathways increasing the amplitude and diversity of downstream signals.\u003cbr\u003e\nErbB2 is significantly associated with breast cancer and gastric cancer. The overexpression or gene amplification of HER2 is observed in approximately 20% of breast cancer cases correlating with aggressive tumor growth and poor prognosis. ErbB2-related signaling contributes to oncogenic processes by promoting excessive cell proliferation. Targeting ErbB2 in these cancers is common using therapies such as monoclonal antibodies like trastuzumab. In the context of gastric cancer the role of ErbB2 mirrors its function in breast cancer and targeting HER2 holds therapeutic potential.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848478970025,"sku":"ab16662","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab16662","provider":"Iright","version":"1.0","type":"link"}