{"product_id":"abcam-ab166898","title":"Abcam, ab166898, Anti-Trypsinogen antibody [EPR11665(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal PRSS2 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11665(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTrypsinogen also known as inactive trypsin is a precursor molecule that becomes active trypsin in the digestive system. It has a molecular mass of approximately 24 kDa. Secretory cells of the pancreas express trypsinogen and it is released into the small intestine as an inactive enzyme. In the small intestine enteropeptidase cleaves trypsinogen to form active trypsin which is important in digestion.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTrypsinogen plays a role in converting proteins to peptides in the small intestine. It is part of the digestive system and contributes to the breakdown and absorption of proteins. Once activated to trypsin it works in tandem with other digestive enzymes like chymotrypsin and elastase. This teamwork ensures efficient digestion and absorption of nutrients.\u003cbr\u003e\nPathways\u003cbr\u003e\nTrypsinogen is an important component in the digestive enzyme cascade. It plays a critical role in the proteolytic pathway which includes proteins like chymotrypsinogen and procarboxypeptidase. Activation of trypsin by enteropeptidase also promotes the activation of other zymogens thereby ensuring complete conversion of these inactive precursors to active enzymes vital for maintaining protein digestion.\u003cbr\u003e\nAn accumulation of trypsinogen can link to pancreatitis. This condition occurs when trypsinogen is prematurely activated within the pancreas leading to inflammation and tissue damage. Hereditary pancreatitis involves mutations in trypsinogen that result in increased autoactivation. Additionally cystic fibrosis can interfere with trypsinogen secretion and activation affecting pancreatic and digestive functions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844188688553,"sku":"ab166898","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab166898","provider":"Iright","version":"1.0","type":"link"}