{"product_id":"abcam-ab167192","title":"Abcam, ab167192, Anti-KLF15 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal KLF15 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLF15.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human KLF15.Q9UIH9\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKLF15 also known as Kruppel-like factor 15 works mechanically as a transcription factor. The KLF15 protein with a molecular mass of approximately 44 kDa functions by regulating the expression of genes involved in metabolism and cell differentiation. It is expressed in various tissues including the heart liver and skeletal muscle. This expression suggests that the KLF-15 protein plays a significant role in maintaining tissue-specific functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nKLF15 influences several cellular processes by regulating gene expression. It is part of a transcription factor complex that modulates glucose metabolism lipid metabolism and muscle differentiation. The KLF-15 protein contributes to maintaining homeostasis by upregulating genes responsible for gluconeogenesis and lipid usage which is essential in adapting to fasting states. Additionally it impacts muscle cell differentiation by influencing the expression of specific myogenic factors.\u003cbr\u003e\nPathways\u003cbr\u003e\nKLF15 is significant in metabolic and myogenic pathways. It upregulates genes involved in the gluconeogenesis pathway and fatty acid oxidation collaborating with proteins such as PGC-1α. Additionally within myogenic pathways KLF-15 protein interacts with myogenic regulatory factors contributing to muscle differentiation. These interactions highlight its importance in metabolic and muscle function pathways and highlight its regulatory capacity across different biological processes.\u003cbr\u003e\nKLF15 has important roles. Alterations in KLF-15 protein levels link to metabolic diseases such as diabetes and cardiac hypertrophy. In diabetes it affects glucose metabolism and insulin sensitivity with connections to proteins like FOXO1. In cardiac hypertrophy KLF-15 influences structural remodeling of the heart potentially interacting with hypertrophy-associated factors. This connection to diseases emphasizes its potential as a therapeutic target for related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848607355049,"sku":"ab167192","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab167192","provider":"Iright","version":"1.0","type":"link"}