{"product_id":"abcam-ab167390","title":"Abcam, ab167390, Anti-Sodium Potassium ATPase antibody [EP1845Y] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nAnti-Sodium Potassium ATPase antibody [EP1845Y] - BSA and Azide free (ab167390) is a rabbit recombinant monoclonal antibody for  Western Blot, Flow Cytometry, IHC-P, ICC\/IF.  Suitable for  Chinese hamster, Human, Mouse, Rat . - BSA, sodium azide, and glycerol-free for easy conjugation - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP1845Y,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human, Chinese hamster,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody recognizes an intracellular epitope of Sodium\/potassium-transporting ATPase alpha-1 subunit.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Sodium Potassium ATPase antibody [EP1845Y] - BSA and Azide free (ab167390) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Chinese hamster, Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of Sodium Potassium ATPase?\u003cbr\u003e\nAnti-Sodium Potassium ATPase [EP1845Y] - BSA and Azide free (ab167390) specifically detects a band for Sodium Potassium ATPase (UniProt: P05023) at a molecular weight of 113kDa.\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EP1845Y] also available for your convenience:\u003cbr\u003e\nab76020\u003cbr\u003e\n, Carrier free - ab167390, HRP -\u003cbr\u003e\nab185065\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab197713\u003cbr\u003e\n, Biotin -\u003cbr\u003e\nab198366\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab198367\u003cbr\u003e\n, PE -\u003cbr\u003e\nab209299\u003cbr\u003e\n, Alexa Fluor® 405 -\u003cbr\u003e\nab210143\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab274883\u003cbr\u003e\nab283318\u003cbr\u003e\n, Carrier free -\u003cbr\u003e\nab283340\u003cbr\u003e\n, Carrier free -\u003cbr\u003e\nab283341\u003cbr\u003e\nab283345\u003cbr\u003e\n, APC -\u003cbr\u003e\nab314288\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb\u003cbr\u003e\npatents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Sodium Potassium ATPase also known as Na\/K-ATPase or NaK Pump is an essential enzyme that performs active transport of sodium (Na+) and potassium (K+) ions across the plasma membrane. This transmembrane protein has a molecular weight typically ranging from 100 to 120 kDa. It is expressed in most cell types particularly abundant in nerve and muscle cells. The ATPase hydrolyzes ATP to drive the exchange of three intracellular sodium ions for two extracellular potassium ions maintaining vital gradients across the cell membrane.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Na\/K ATPase plays an important role in maintaining cellular homeostasis and membrane potential. It is an integral component of the cell membrane often operating as part of larger multiprotein complexes. This pump is responsible for providing the driving force behind secondary transport systems by maintaining ionic gradients. The presence of Na\/K ATPase is also important for the functioning of the nervous system as it helps propagate action potentials in neurons.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe Na\/K ATPase is integral to the regulation of cardiac contraction and nerve signal transmission. It participates in pathways like the cardiac glycoside pharmacodynamics and the sodium ion transport pathway. It interacts with proteins such as ankyrin which link the ATPase to the cellular cytoskeleton facilitating its distribution and stability within the cell membrane. These interactions are significant for ensuring precise ion homeostasis and efficient cellular operation.\u003cbr\u003e\nNa\/K ATPase is linked to conditions such as hypertension and congestive heart failure. These diseases are associated with improper functioning or regulation of the ATPase which affects sodium and potassium balance and blood pressure regulation. The target also interacts with the protein PLM (phospholemman) which modulates its activity under different physiological and pathological conditions. Malfunction or mutations in the genes encoding Na\/K ATPase subunits can contribute to neurological and cardiovascular disorders making it a therapeutic target in associated treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844139602089,"sku":"ab167390","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab167390","provider":"Iright","version":"1.0","type":"link"}