{"product_id":"abcam-ab168810","title":"Abcam, ab168810, Anti-ASCC3 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ASCC3 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ASCC3 aa 2150 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ASCC3 aa 2150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8N3C0\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab168810 was affinity purified using an epitope specific to ASCC3 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nASCC3 also known as Activating Signal Cointegrator 1 Complex Subunit 3 is a component of the ASC-1 complex involved in transcription regulation and DNA repair activities. It has a mass of around 145 kDa and is expressed in multiple tissues including the brain and other neuronal tissues. This protein plays an essential mechanical role as a helicase which is involved in the unwinding of DNA and RNA influencing how genetic information is read and processed by the cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nASCC3 contributes to cellular responses to DNA damage. It functions as part of the ASC-1 complex which also includes subunits ASCC1 ASCC2 and TRIP4. This complex participates in recruiting other factors to sites requiring repair thereby maintaining genomic stability. The helicase activity of ASCC3 ensures proper transcript processing affects cellular growth and survival under stress conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nASCC3 is involved in DNA damage response and repair pathways. Particularly it engages with the nucleotide excision repair (NER) pathway where it affects how cells respond to UV-induced DNA damage. ASCC3 works in conjunction with proteins like XPA and RPA which share roles in recognizing and repairing damaged DNA. This coordination emphasizes ASCC3's relevance to genomic integrity and response to environmental changes.\u003cbr\u003e\nASCC3 has been associated with neurological disorders and cancer. Mutations or dysfunctions in ASCC3 can lead to improper DNA repair which increases susceptibility to cancerous transformations. Additionally ASCC3 shows interaction with other proteins related to neuronal health like ASCC1 and mutations in these proteins have been linked to neurodevelopmental disorders. Accurate study of ASCC3's role could help in understanding disease mechanisms and potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853998608553,"sku":"ab168810","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab168810","provider":"Iright","version":"1.0","type":"link"}