{"product_id":"abcam-ab168945","title":"Abcam, ab168945, Anti-USP2 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal USP2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human USP2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human USP2.O75604\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUSP2 often referred to as ubiquitin-specific peptidase 2 is a deubiquitinating enzyme. This enzyme removes ubiquitin molecules from protein substrates a process necessary for regulating protein degradation. With a molecular weight of about 65 kDa USP2 regulates protein turnover and stability within the cell. This enzyme is widely expressed across various tissues including the heart liver and kidneys highlighting its significant involvement in cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUSP2 takes part in maintaining protein quality control and is essential in the protein degradation pathway. It functions as a member of the ubiquitin-proteasome system an important complex that ensures proteins are degraded timely after fulfilling their roles in cellular events. This degradation process is key for cellular homeostasis and affects numerous functions such as transcription DNA repair and cell cycle regulation.\u003cbr\u003e\nPathways\u003cbr\u003e\nUSP2 is known to participate in the ubiquitin-proteasome pathway a fundamental process for protein catabolism in cells. It interacts with other proteins such as Mdm2 which is involved in the p53 signaling pathway that regulates the cell cycle. The interaction with these pathways illustrates USP2’s role in managing protein stability and cellular responses to stress.\u003cbr\u003e\nAltered USP2 activity has connections to cancer and metabolic disorders notably diabetes. Abnormal activity of USP2 can influence the degradation of proteins that regulate cell growth and metabolism which can lead to tumorigenesis. It is closely linked with Mdm2 in cancer as disruptions in their interaction may influence the regulation of tumor suppressor proteins ultimately impacting cancer progression and treatment outcomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852264755369,"sku":"ab168945","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab168945","provider":"Iright","version":"1.0","type":"link"}