{"product_id":"abcam-ab169442","title":"Abcam, ab169442, Anti-Enterovirus 71 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal POLG antibody. Carrier free. Suitable for WB and reacts with Transfected cell lysate - Enterovirus A71 samples. Cited in 13 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human enterovirus 71 (strain BRCR) Genome polyprotein.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Enterovirus A71,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human enterovirus 71 (strain BRCR) Genome polyprotein.Q66478,\u003cbr\u003e\nSpecificity:This antibody is specific for the Protein VP1 cleaved chain of Genome polyprotein. The complete proteome is Human enterovirus 71 (Ev 71).\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEnterovirus 71 (EV71) also known as enteroviral VP1 is a significant member of the enterovirus genus. Mechanically EV71 is a small RNA virus with a protein capsid that is important for viral replication and cell infection. The virus is around 30 nm in diameter and the capsid proteins including VP1 play an important role in its structure and function. EV71 is primarily expressed in human tissues that include the gastrointestinal tract and central nervous system. The VP1 protein is essential for receptor recognition and mediates the attachment of the virus to host cells facilitating the entry of the viral RNA into the host cell.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEV71 infects host cells and hijacks the cellular machinery to replicate itself causing cytopathic effects. The VP1 protein is a critical part of the viral capsid complex and interacts with host cell receptors initiating infection. This process causes the host cell to undergo apoptosis and releases new viral particles perpetuating the infection cycle. EV71 plays a substantial role in disrupting host cellular processes which then leads to notable clinical symptoms.\u003cbr\u003e\nPathways\u003cbr\u003e\nEV71 interacts with host cellular pathways involved in viral replication and immune response. Specifically the virus can affect the signal transduction pathways important for the host's antiviral defenses such as the type I interferon pathway. This interaction allows the virus to evade the immune system temporarily. Additionally EV71 affects the proteasome pathway that includes proteins related to antigen presentation which is essential for an adequate immune response by the host.\u003cbr\u003e\nEV71 is most notably associated with hand foot and mouth disease and can cause severe neurological complications like encephalitis. The virus can affect young children severely and outbreaks have led to significant health concerns in various regions. EV71 interacts with proteins involved in immune surveillance such as those within the interferon response pathways which play a critical role in the pathogenesis of its related diseases. Understanding this interaction is important for developing therapeutic monoclonal antibodies such as mab979 that can target EV71 infections.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852263051433,"sku":"ab169442","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab169442","provider":"Iright","version":"1.0","type":"link"}