{"product_id":"abcam-ab169490","title":"Abcam, ab169490, Anti-FUT6 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal FUT6 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FUT6.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human FUT6.P51993\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFUT6 also known as fucosyltransferase 6 is an enzyme with a molecular mass of approximately 45 kDa. This enzyme mechanically transfers fucose a type of sugar to N-glycans found on cell surfaces. FUT6 achieves this through an α13 or α14-glycosidic linkage. Expression of FUT6 occurs mainly in the liver and gastrointestinal tract indicating its role in tissues involved in metabolism and digestion.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis enzyme plays a role in the biosynthesis of the Lewis blood group antigens which are important for cell-cell interactions. These interactions occur during processes like immune responses and cellular differentiation. FUT6 functions in this context without forming part of larger protein complexes. Its activity directly affects the modification of oligosaccharides to present selectin ligands which facilitates cellular adhesion.\u003cbr\u003e\nPathways\u003cbr\u003e\nFUT6 is an essential player in the fucosylation pathway impacting glycoprotein and glycolipid metabolism. It interacts closely with other members of the fucosyltransferase family such as FUT4 to modulate synthesis of sialyl Lewis x epitopes. These pathways are instrumental in regulating leukocyte extravasation during immune surveillance and inflammation.\u003cbr\u003e\nFUT6 shows significant relevance to inflammatory diseases and certain types of cancer. Abnormal expression of this enzyme has links to colorectal cancer progression due to altered glycan structures on the cell surface. Additionally FUT6 in connection with other fucosyltransferases like FUT3 relates to inflammatory bowel disease where changes in glycosylation patterns might contribute to pathogenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852264067241,"sku":"ab169490","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab169490","provider":"Iright","version":"1.0","type":"link"}