{"product_id":"abcam-ab169773","title":"Abcam, ab169773, Anti-SPANXD antibody [EPR8902]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SPANXD antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8902,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSPANXD also known as Sperm Protein Associated with the Nucleus on the X Chromosome Family Member D is a protein with a molecular weight of approximately 11 kDa. SPANXD shows expression mainly in the testis and has a specific role during spermatogenesis. This protein belongs to the SPANX gene family which is particularly known for its expression in male germ cells. Additionally SPANXD appears to localize in the nucleus where it may play a role in chromatin organization during sperm development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSPANXD functions in facilitating the proper packaging and organization of sperm chromatin ensuring genomic integrity during reproduction. It likely contributes to the final stages of sperm maturation particularly affecting chromatin condensation through interaction with the nuclear matrix. Although not extensively reported as part of large protein complexes SPANXD may work in conjunction with other SPANX family members to achieve its functional roles during sperm cell development.\u003cbr\u003e\nPathways\u003cbr\u003e\nSPANXD plays a part in the reproductive cellular pathways by ensuring the integrity and proper compaction of DNA in sperm cells. It is involved in spermatogenesis where it helps regulate the chromatin condensation process critical for functional sperm cells. Related proteins involved in these pathways include other family members like SPANXA and SPANXB which together may facilitate coordinated events during sperm cell development.\u003cbr\u003e\nResearchers link SPANXD to fertility issues particularly male infertility due to its sperm-specific expression and function. Abnormal SPANXD expression or dysfunction can result in improper sperm development. Its connection to SPANX family members suggests combined impacts on spermatogenesis where disruptions can lead to azoospermia or oligospermia. Understanding SPANXD's role could contribute to developing targeted treatments for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850347040937,"sku":"ab169773","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab169773","provider":"Iright","version":"1.0","type":"link"}