{"product_id":"abcam-ab170106","title":"Abcam, ab170106, Anti-Cytokeratin 2e antibody [EPR10911]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal K22E antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR10911,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCytokeratin 2e also known as keratin 2 or KRT2 is a type of intermediate filament protein with a mass of approximately 65 kDa. It functions mechanically to form and maintain structural integrity in epithelial cells. Cytokeratin 2e forms part of the keratin cytoskeleton which gives cells shape support and resilience against mechanical stress. This protein is expressed mainly in the upper spinous layer of the epidermis where it contributes to the specialized cytokeratin network.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCytokeratin 2e participates in cell differentiation and maturation within the epidermis. It does not operate in isolation but is integrated into a complex network of filaments comprising various keratin isoforms. This structured network assists in the development of the skin barrier which is essential for protecting the body from environmental damage. By facilitating the cohesion between keratinocytes Cytokeratin 2e plays a role in maintaining proper epidermal function.\u003cbr\u003e\nPathways\u003cbr\u003e\nCytokeratin 2e involves the epidermal differentiation pathway. It interacts primarily with other keratin proteins like keratin 1 (KRT1) to enhance the formation of a robust keratinocyte cytoskeleton. This association ensures proper skin cell function and epidermis homeostasis. The protein is also involved in the cornification pathway helping the process whereby keratinocytes become corneocytes the cells that make up the skin's outermost layer.\u003cbr\u003e\nCytokeratin 2e has links to ichthyosis bullosa of Siemens a keratinization disorder. Mutations affecting Cytokeratin 2e disrupt the structural stability of keratin filaments leading to skin fragility and blistering. Additionally its aberrant expression has associations with psoriasis where it may interact with immune-modulatory proteins like interleukin-17 (IL-17) aggravating the inflammatory environment. Understanding these connections helps in exploring therapeutic targets for managing these skin conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850391277737,"sku":"ab170106","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab170106","provider":"Iright","version":"1.0","type":"link"}