{"product_id":"abcam-ab171934","title":"Abcam, ab171934, Anti-POGZ antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal POGZ antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human POGZ aa 1-600.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human POGZ aa 1-600. The exact immunogen used to generate this antibody is proprietary information.Q7Z3K3\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Purification notes-Sterilized by filtration through 0.22 µm membrane., Storage buffer-pH: 6.5 - 8.5, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPOGZ also known as Pogo Transposable Element with ZNF Domain is a zinc finger protein with a molecular weight of approximately 155 kDa. Scientists have studied POGZ for its role in transcription regulation. This protein localizes primarily in the nucleus and is expressed in various human tissues with higher expression levels observed in the brain. POGZ interacts with chromatin and may play a role in the regulation of gene expression through chromatin remodeling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPOGZ influences genetic expression by participating in the chromatin modification process. It acts as a member of the protein complex that includes histone modifiers modifying the chromatin landscape to allow or restrict access for transcription machinery. The protein impacts neuronal differentiation and brain development among other processes therefore bearing significance in neurodevelopmental biology. It partners with several key proteins to achieve its biological functions contributing to the regulation of genes required for proper cellular function.\u003cbr\u003e\nPathways\u003cbr\u003e\nMore than one biological pathway has involved POGZ. Notably it participates in the chromatin remodeling pathway important for modulating chromatin structure and gene accessibility. POGZ interacts with proteins such as CHD4 part of the NuRD complex within these pathways. These interactions facilitate access to DNA regulating the transcription of genes tied to cellular differentiation and proliferation.\u003cbr\u003e\nGenetics has linked POGZ to neurodevelopmental disorders such as intellectual disability and autism spectrum disorder (ASD). Mutations in the POGZ gene disrupt normal function contributing to these conditions. POGZ has connections with ATRX another protein associated with intellectual disabilities. Research continues to explore how these interactions contribute to the pathogenesis of neurodevelopmental disorders offering potential therapeutic targets in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850141880489,"sku":"ab171934","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab171934","provider":"Iright","version":"1.0","type":"link"}