{"product_id":"abcam-ab171947","title":"Abcam, ab171947, Anti-SKAP55 antibody [EPR11359]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SKAP55 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11359,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSKAP55 also known as Src kinase-associated phosphoprotein 55 is a protein with a mass of approximately 55 kDa. It plays an important role in T-cell signaling. This protein mainly expresses in lymphoid tissues including the thymus spleen and peripheral blood lymphocytes. SKAP55 interacts with signaling molecules via its SH3 domain facilitating cellular communication and activation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein functions as an adapter molecule in T-cell receptor (TCR) signaling pathways. SKAP55 associates with the LAT-Gads complex contributing to intracellular signal transduction. It helps mediate actin cytoskeletal rearrangements necessary for immune synapse formation. These rearrangements are critical for effective immune response meaning SKAP55 is integral to T-cell activation and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nSKAP55 participates in the signaling events downstream of the TCR particularly in the PI3K and Ras-MEK-ERK pathways. It works closely with proteins like LCK and ZAP70 which are essential for the phosphorylation processes involved in T-cell activation. Through these interactions SKAP55 influences the organization of signaling assemblies promoting effective cellular responses.\u003cbr\u003e\nSKAP55 relates to immune system-related conditions like autoimmune diseases and immunodeficiencies. Alterations in SKAP55 expression or function can affect T-cell signaling potentially leading to improper immune responses. SKAP55 interactions with LCK can influence diseases such as systemic lupus erythematosus where immune regulation is disrupted highlighting its importance in maintaining immune system balance.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850448261289,"sku":"ab171947","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab171947","provider":"Iright","version":"1.0","type":"link"}