{"product_id":"abcam-ab171968","title":"Abcam, ab171968, Anti-CACNA1F antibody [EPR11822]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CACNA1F antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11822,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CACNA1F gene encodes the alpha-1F subunit of a voltage-dependent L-type calcium channel. This protein also known as Cav1.4 has a mass of approximately 230 kDa. It facilitates the influx of calcium ions into the cells in response to changes in electric potential across the cell membrane. The protein is expressed mainly in the retina where it plays an important role in the function of photoreceptor cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe CACNA1F protein influences neurotransmitter release by regulating calcium entry which is essential for visual processing. It functions as a part of a larger voltage-gated calcium channel complex where its role is to fine-tune calcium signals. This precise control is necessary for the proper response to light stimuli in the eye allowing effective signal transmission to the visual pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe CACNA1F protein integrates into the calcium signaling pathway important for neuronal communication and sensory processes. It is also linked to the phototransduction cascade in the retina. Within these pathways CACNA1F interacts with related proteins like beta subunits that modulate the activity of the L-type calcium channels impacting overall visual function.\u003cbr\u003e\nMutations in the CACNA1F gene are associated with X-linked congenital stationary night blindness and other retinal disorders. These conditions can lead to an impaired vision due to the disrupted calcium flow in photoreceptors. Additionally CACNA1F shows a relationship with other calcium channel proteins like CACNA1S potentially influencing disorder phenotypes through altered ionic homeostasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850454225065,"sku":"ab171968","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab171968","provider":"Iright","version":"1.0","type":"link"}