{"product_id":"abcam-ab172276","title":"Abcam, ab172276, Anti-SCNN1B antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal SCNN1B antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SCNN1B.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human SCNN1B.P51168\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSCNN1B also known as the beta subunit of the epithelial sodium channel (ENaC) is a critical component in sodium ion transport across epithelial cells. SCNN1B has a molecular mass of approximately 92 kDa. It is primarily expressed in epithelial tissues like the kidney lung and colon where it contributes to maintenance of sodium balance and regulation of fluid homeostasis. The protein plays an essential role in controlling sodium absorption which is necessary for various physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSCNN1B is a part of the epithelial sodium channel complex which includes two other subunits: SCNN1A (alpha) and SCNN1G (gamma). Together with these subunits SCNN1B facilitates the selective transport of sodium ions impacting processes such as blood pressure regulation and airway surface liquid homeostasis. The channel formed by these subunits operates under guidance by aldosterone a hormone that influences its assembly and activity.\u003cbr\u003e\nPathways\u003cbr\u003e\nSCNN1B takes part in the Renin-Angiotensin-Aldosterone System (RAAS) and sodium reabsorption pathways. These are vital for maintaining electrolyte balance and blood pressure regulation. SCNN1B interacts closely with proteins such as Nedd4-2 which modulates its activity by influencing channel degradation. This interaction ensures that sodium transport and fluid balance remain tightly regulated.\u003cbr\u003e\nAbnormalities in SCNN1B function relate to conditions like Liddle syndrome and hypertension. Mutations causing hyperactivity of the channel can lead to excessive sodium reabsorption resulting in these conditions. Furthermore SCNN1B has connections with other proteins like SGK1 which plays a regulatory role in adapting sodium channel activity. Understanding these links is important for targeting these conditions with medical therapies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852278485161,"sku":"ab172276","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab172276","provider":"Iright","version":"1.0","type":"link"}