{"product_id":"abcam-ab172623","title":"Abcam, ab172623, Anti-eIF1A antibody [EPR12467]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal eIF1A antibody. Suitable for IHC-P, IP, WB, ICC\/IF and reacts with Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12467,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEIF1A also known as Eukaryotic Initiation Factor 1A plays an important role in the process of initiating translation. It has a mass of approximately 17.5 kDa. This factor is expressed in various tissues playing a role in forming the pre-initiation complex ensuring mRNA and ribosomal alignment. eIF1A's structure and binding capabilities make it an essential component for the fidelity and efficiency of translation initiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEIF1A functions as part of the eukaryotic translation initiation complex. It stabilizes the binding of the small ribosomal subunit to mRNA. eIF1A works closely with other initiation factors including eIF1 eIF3 and eIF5 to facilitate the proper scanning of mRNA for the correct start codon. This precise role in translation initiation serves as a regulatory point for protein synthesis in cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nEIF1A engages in the mRNA translation pathway particularly in the initiation phase. It is critical in ensuring the mRNA translation accuracy by preventing premature joining of the large ribosomal subunit. eIF1A associates with proteins like eIF3 and eIF2 during the initial stages of translation. This involvement ensures cellular homeostasis and efficient cellular response to various stimuli.\u003cbr\u003e\nEIF1A may influence cancer development and progression. Alterations in its expression levels or mutations can disrupt normal translation processes potentially leading to oncogenesis. Research indicates a connection between eIF1A and tumor suppressor proteins highlighting its impact on cellular proliferation. Additionally eIF1A may relate to neurodegenerative disorders by affecting proteins such as eIF2 impacting neuronal translation control and protein synthesis regulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850286715049,"sku":"ab172623","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab172623","provider":"Iright","version":"1.0","type":"link"}