{"product_id":"abcam-ab174272","title":"Abcam, ab174272, Anti-KRTHB3 antibody [EPR12333]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal KRTHB3 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12333,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKRTHB3 also known as Type I Hair Keratin 3 is a structural protein that plays an integral role in the formation of hair and nail cells. Its molecular mass is approximately 66 kDa. It is expressed in hair follicles and nails where it contributes to the robustness and integrity of these tissues. The protein is a component of the intermediate filament family which provides mechanical strength to cells by forming part of the cytoskeleton.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe functional units of hair and nail cells utilize KRTHB3 as part of the cytoskeletal framework ensuring the structural integrity essential for normal growth and development. KRTHB3 is also an important component of the keratin filament network which forms a fibrous matrix. It often works in tandem with other keratin proteins such as KRTHB1 and KRTHB2 forming heterodimers that create a durable structure in keratinized tissues.\u003cbr\u003e\nPathways\u003cbr\u003e\nKRTHB3 operates as a constituent of the keratinization process and plays a major role in the epithelial cell differentiation pathway. These pathways are important for the development of hair nails and skin. In these processes KRTHB3 interacts with other structural proteins like desmoplakin and envoplakin which are integral for cell adhesion and forming the epidermis barrier.\u003cbr\u003e\nKRTHB3 mutations or dysregulation can relate to conditions like alopecia and nail dystrophy. Abnormalities in the expression of KRTHB3 can lead to weakened hair or nail structures due to improper keratin formation. In some cases these conditions may also involve interactions with other proteins such as filaggrin a protein known to contribute to skin barrier function and hydration exacerbating the severity of these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850319679657,"sku":"ab174272","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab174272","provider":"Iright","version":"1.0","type":"link"}