{"product_id":"abcam-ab174291","title":"Abcam, ab174291, Anti-EPS15 antibody [EP9280]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Monoclonal EPS15 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 8 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP9280,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEPS15 also known as Epidermal Growth Factor Receptor Substrate 15 is a critical adaptor protein involved in the process of endocytosis. The protein has a molecular mass of approximately 105 kDa and is highly expressed in various tissues particularly in the nervous system. EPS15 acts as an important player in clathrin-mediated endocytosis by interacting with components of endocytic machinery such as clathrin and AP2 adaptor complexes. It also contains multiple EH domains which facilitate protein-protein interactions needed for the internalization of receptors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe EPS15 protein contributes to the regulation of cell surface receptors and is involved in the recycling of these receptors back to the membrane or directing them to lysosomal degradation. This protein partakes in the formation of the clathrin-coated pits which are essential for the invagination of the membrane in the endocytic process. EPS15 works within a complex that aids in trafficking signals within cells allowing cells to maintain homeostasis by dynamically responding to external stimuli.\u003cbr\u003e\nPathways\u003cbr\u003e\nEPS15 significantly influences the endocytosis and EGFR signaling pathways. The protein facilitates the downregulation of receptor tyrosine kinase signaling by mediating the internalization and recycling of the epidermal growth factor receptor (EGFR). EPS15 also interacts with other proteins such as Grb2 and Epsin which are integral to these pathways. The relationship between EPS15 and these pathways highlights its importance in cell communication and proliferation control.\u003cbr\u003e\nDysfunction of EPS15 links to cancer and neurological disorders. Abnormalities in EPS15 expression or function can contribute to cancer progression by disrupting EGFR signaling leading to unregulated cell growth and division. In neurological contexts altered EPS15 expression may affect synaptic transmission and faulty receptor trafficking potentially playing a role in neurodegenerative diseases. The interaction between EPS15 and proteins like EGFR and Epsin emphasizes its involvement in pathological conditions suggesting potential therapeutic targets for certain diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850366865577,"sku":"ab174291","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab174291","provider":"Iright","version":"1.0","type":"link"}