{"product_id":"abcam-ab174297","title":"Abcam, ab174297, Anti-LIN7A antibody [EPR12609]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal LIN7A antibody. Suitable for IP, WB and reacts with Human, Rat, Mouse samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12609,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLIN7A also known as Lin-7 homolog A or MALS-1 is a protein with a molecular weight of approximately 25 kDa. It plays a significant mechanical role in cell signaling and synaptic assembly. LIN7A primarily localizes at cell membranes with pronounced expression in the brain and heart where it participates in the development and maintenance of cellular polarity and tight junctions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLIN7A is involved in neuronal signaling and synaptic function. It forms part of the larger complex known as the membrane-associated guanylate kinase (MAGUK) protein family. In neurons LIN7A maintains receptor localization by interacting with synaptic proteins and is essential in stabilizing various complexes necessary for synaptic communication.\u003cbr\u003e\nPathways\u003cbr\u003e\nLIN7A participates significantly in the MAPK and PI3K\/Akt signaling pathways. These pathways are important in regulating cell growth and survival. LIN7A interacts with other proteins like DLG1 and CASK which are essential components in maintaining cellular signaling integrity within these pathways.\u003cbr\u003e\nDisruptions in LIN7A expression or function have connections with neurological disorders such as schizophrenia and autism spectrum disorders. LIN7A’s interaction with other proteins such as DLG4 suggests its involvement in synaptic dysfunctions which are common characteristics in these conditions. Understanding LIN7A's roles in these disorders can potentially lead to targeted therapeutic approaches.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850308964521,"sku":"ab174297","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab174297","provider":"Iright","version":"1.0","type":"link"}