{"product_id":"abcam-ab174305","title":"Abcam, ab174305, Anti-ING2 antibody [EPR4597-5]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ING2 antibody. Suitable for IP, WB and reacts with Mouse, Recombinant full length protein, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR4597-5,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nRat: We have preliminary internal testing data to indicate this antibody may not react with this species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nING2 also known as Inhibitor of Growth Protein 2 is a nuclear protein with a molecular weight of approximately 33 kDa. It expresses highly in tissues such as the prostate placenta and lung. Nuclear localization signals and PHD-finger motifs characterize its structure allowing it to bind to chromatin and influence gene expression. As a member of the ING family ING2 plays a role in regulating various cellular processes through its presence in different cellular compartments.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nING2 functions as a tumor suppressor by controlling the transcription of genes involved in cell cycle regulation and apoptosis. It interacts with histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes contributing to chromatin remodeling. As part of the Sin3A-HDAC complex ING2 has the ability to repress transcription influencing the expression of genes important for maintaining cellular homeostasis and preventing oncogenesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe ING2 protein actively participates in the p53 signaling pathway as well as the MAPK signaling pathway. Its interaction with p53 leads to the enhancement of p53-mediated transcriptional activation which promotes cell cycle arrest and apoptosis. ING2 also interacts with proteins like TP53 and EP300 modulating the cellular responses to stress signals and contributing to cell survival and repair mechanisms.\u003cbr\u003e\nThe involvement of ING2 has been linked to cancer and neurodegenerative disorders. In cancer downregulation or mutation of ING2 disrupts the p53 pathway leading to impaired tumor suppression. ING2's interaction with TP53 and its tumor suppressor role highlights its importance in cancer biology. Furthermore in neurodegenerative disorders ING2's dysregulation can influence neuronal survival pathways potentially affecting proteins like p53 and EP300 therefore altering neuronal function and contributing to disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850226356393,"sku":"ab174305","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab174305","provider":"Iright","version":"1.0","type":"link"}