{"product_id":"abcam-ab175207","title":"Abcam, ab175207, Anti-MRPS17 antibody [EPR12583]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal MRPS17 antibody. Suitable for IHC-P, IP, WB, ICC\/IF and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12583,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-P, IP, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMRPS17 also known as mitochondrial ribosomal protein S17 is a component of the mitochondrial ribosome small subunit. It weighs approximately 17 kDa. MRPS17 expresses in tissues throughout the body especially in those with high-energy requirements like muscle and brain. MRPS17 is essential for mitochondrial protein synthesis where it contributes to translating mitochondrial-encoded messages into functional proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein MRPS17 acts as part of the mitochondrial ribosome which contains many different proteins and ribosomal RNA. This complex plays a significant role in cellular energy metabolism by producing proteins essential for the electron transport chain. MRPS17 ensures that mitochondria maintain their capacity to synthesize proteins that drive ATP production. Without this process cells would lack adequate energy supply.\u003cbr\u003e\nPathways\u003cbr\u003e\nMRPS17 engages in critical roles within mitochondrial translation pathway and oxidative phosphorylation pathway. These pathways facilitate the proper function of mitochondria in energy production. MRPS17 interacts with other mitochondrial ribosomal proteins like MRPS18 ensuring the accuracy and efficiency of protein synthesis. This interaction supports overall mitochondrial and cellular health.\u003cbr\u003e\nDefects in MRPS17 relate to mitochondrial diseases such as Leigh syndrome and mitochondrial cardiomyopathy. These conditions often arise from disrupted energy production in cells. Genetic mutations affecting MRPS17 might impair mitochondrial function leading to clinical symptoms. MRPS17 shares connections with other mitochondrial proteins like MRPS16 in the context of these disorders highlighting its relevance in related pathological states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850382528681,"sku":"ab175207","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab175207","provider":"Iright","version":"1.0","type":"link"}