{"product_id":"abcam-ab175213","title":"Abcam, ab175213, Anti-Ribosomal protein S11\/RPS11 antibody [EPR11487]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Ribosomal protein S11\/RPS11 antibody. Suitable for IHC-P, WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11487,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra), ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRibosomal protein S11 also known as RPS11 or BSA S11 is a component of the small 40S subunit of ribosomes. It has a mass of about 18.8 kDa. RPS11 is expressed across various tissues essential for protein synthesis in eukaryotic cells. It plays a mechanical role in facilitating the assembly and proper function of the ribosome which is critical for translating mRNA into protein.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRPS11 serves as an important player in the ribosomal complex vital for maintaining the structure and function of the ribosome. It assists in the binding of mRNA and tRNA promoting the translation process. The precise arrangement of RPS11 and its interactions with other ribosomal proteins ensures efficient protein synthesis necessary for cell growth and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nRPS11 plays a significant role in the translation mechanism including the mTOR pathway which regulates cell growth in response to nutrients and growth factors. Through this pathway RPS11 works in conjunction with proteins like S6 kinase and 4E-BP1 modulating protein translation rates in various cellular conditions. Additionally RPS11 contributes to the ribosomal biogenesis pathway integrating signals for assembly and function of ribosomes.\u003cbr\u003e\nDisruptions in RPS11 regulation or mutations can lead to conditions such as Diamond-Blackfan anemia characterized by reduced red blood cell production. RPS11's interaction with other ribosomal proteins like RPS19 has been implicated in this disorder. Moreover altered expression of RPS11 may play a role in various cancers influencing tumor growth and malignancy due to abnormal protein synthesis rates.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850276294825,"sku":"ab175213","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab175213","provider":"Iright","version":"1.0","type":"link"}