{"product_id":"abcam-ab175236","title":"Abcam, ab175236, Anti-Oligodendrocyte Specific Protein antibody [EPR12726] - Oligodendrocyte Marker","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Oligodendrocyte Specific Protein antibody. Oligodendrocyte marker. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12726,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOligodendrocyte Specific Protein also known as O4 or O4 protein is an important marker for oligodendrocytes. This protein has a mass of approximately 24 kDa. Predominantly it is expressed in the central nervous system (CNS) specifically in oligodendrocyte precursor cells (OPCs) and mature oligodendrocytes. Its presence marks the differentiation stage of oligodendrocytes serving as an indicator of their development and maturation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe oligodendrocyte marker O4 plays a significant role in the myelination process supporting the formation of the myelin sheath around neurons. O4 does not act as part of a complex but is essential in the identification of oligodendrocyte lineage cells. During development it signals the transition of OPCs into mature myelinating oligodendrocytes which are necessary for effective neuronal signal transmission in the CNS.\u003cbr\u003e\nPathways\u003cbr\u003e\nOligodendrocyte marker O4 influences critical processes in the nervous system namely the myelination pathway. It interacts with various proteins including myelin basic protein (MBP) involved in the formation and maintenance of the myelin sheath. The presence of O4 marks the progression along the oligodendrocyte lineage and fits within the larger framework of CNS development and repair indicating a healthy state of neuronal insulation.\u003cbr\u003e\nDisruptions involving the oligodendrocyte marker O4 can relate to multiple sclerosis (MS) and leukodystrophies. These conditions arise from demyelination or abnormal myelination respectively. O4 in association with other proteins like MBP and proteolipid protein (PLP) can serve as a biomarker for disease activity and progression. Its expression levels may assist in the research and diagnosis of demyelinating diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850455044265,"sku":"ab175236","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab175236","provider":"Iright","version":"1.0","type":"link"}