{"product_id":"abcam-ab176563","title":"Abcam, ab176563, Anti-NDUFA1 antibody [EPR12083]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal NDUFA1 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12083,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNDUFA1 also called NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 is a critical component of the mitochondrial respiratory chain. It has an approximate molecular mass of 5.5 kDa and resides within the inner mitochondrial membrane. This protein is part of the larger NADH:ubiquinone oxidoreductase also known as Complex I which is present across various tissues where energy production is essential. NDUFA1 aids the proper function of Complex I to facilitate electron transfer during cellular respiration.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNDUFA1 plays an integral role in the electron transfer process by linking with other subunits to form the Complex I assembly. It is important for the initial step of the electron transport chain where it helps in transferring electrons from NADH to ubiquitin. This step is important as it contributes to the generation of a proton gradient across the mitochondrial membrane which is necessary for ATP synthesis. Part of the mitochondrial enzymatic pathway NDUFA1 works in concert with other enzyme complexes to maintain cellular energy balance.\u003cbr\u003e\nPathways\u003cbr\u003e\nNDUFA1 engages primarily in the oxidative phosphorylation pathway which is pivotal for ATP production in cells. This pathway connects NDUFA1 with other complexes such as Complex II Complex III and Complex IV ensuring comprehensive electron flow and proton gradient creation. In addition NDUFA1 is involved in the mitochondrial electron transport chain linking with proteins such as cytochrome c for maintaining energy metabolism and cellular respiration.\u003cbr\u003e\nMutations or dysfunctions in NDUFA1 relate to mitochondrial disorders like Leigh syndrome which affect energy-dependent tissues such as the brain and muscles. Such mutations lead to impaired electron transfer therefore causing energy deficits. NDUFA1 mutations can also contribute to cardiac and neurological disorders due to disrupted ATP synthesis. Within these diseases NDUFA1 interacts with other defective proteins of the mitochondrial respiratory chain exacerbating metabolic irregularities and contributing to disease pathogenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850287599785,"sku":"ab176563","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab176563","provider":"Iright","version":"1.0","type":"link"}