{"product_id":"abcam-ab176713","title":"Abcam, ab176713, Anti-SIX4 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal SIX4 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human Homeobox protein SIX4 aa 700 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human Homeobox protein SIX4 aa 700 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9UIU6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab176713 was affinity purified using an epitope specific to SIX homeobox 4 immobilized on solid support, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.2% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSIX4 also known as Sine oculis homeobox homolog 4 is a transcription factor with an approximate mass of 32 kDa. It plays a role in gene regulation by binding to specific DNA sequences influencing the transcription of various genes. SIX4 is predominantly expressed in tissues such as muscle brain and the developing eye. It works in coordination with other proteins impacting the establishment of cell fate and pattern formation during embryonic development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe SIX4 protein facilitates the regulation of genes involved in developmental processes including somitogenesis and myogenesis. It associates with other transcription factors as part of protein complexes to execute its role effectively. Its function is vital in the proper formation of muscle tissue and the development of sensory organs ensuring that cells differentiate as required during growth.\u003cbr\u003e\nPathways\u003cbr\u003e\nSIX4 participates in the Pax-Six-Eya-Dach network which is essential for early organogenesis and cell differentiation. It interacts with Pax family proteins like PAX3 and PAX7 integrating signals that control the activation of downstream genes important for organ development. Additionally SIX4 is involved in the Wnt signaling pathway which maintains stem cell populations and influences cell fate decisions.\u003cbr\u003e\nSIX4 has been linked to developmental anomalies and muscular dystrophies. Mutations or misregulation in the expression of SIX4 can lead to conditions such as Bosch-Boonstra-Schaaf optic atrophy syndrome. This disorder involves proteins like PAX6 which interact with SIX4 illustrating their interconnected roles in ocular development. Understanding how SIX4 functions can provide insights into therapeutic approaches for these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853940871337,"sku":"ab176713","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab176713","provider":"Iright","version":"1.0","type":"link"}