{"product_id":"abcam-ab176717","title":"Abcam, ab176717, Anti-ETV3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal ETV3 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ETV3 aa 450-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ETV3 aa 450-500. The exact immunogen used to generate this antibody is proprietary information.P41162\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab176717 was affinity purified using an epitope specific to ETV3 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: 99% Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nETV3 also known as ETS Variant 3 functions as a transcriptional repressor. The protein has a mass of approximately 61 kDa. It is expressed in multiple tissues including skin liver and immune cells. The presence of ETV3 is important for regulating gene expression as it can bind to specific DNA sequences and inhibit transcription of target genes. This ability allows ETV3 to maintain control over cellular processes such as proliferation and differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe functionality of ETV3 extends to modulation of immune responses and cellular development. ETV3 along with other transcription factors forms parts of multi-protein complexes. Its role in these complexes involves the repression of gene activity directly influencing cell cycle progression and immune system activity. ETV3’s expression and interactions suggest it coordinates with other molecules to maintain homeostasis and appropriate cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nETV3 integrates into two main biological pathways: the MAPK signaling pathway and immune response regulation. Within the MAPK pathway ETV3 interacts with proteins such as ERK influencing cell survival and differentiation outcomes. Meanwhile it connects in immune pathways by modulating activity of other transcription factors impacting immune cell behaviors and responses.\u003cbr\u003e\nETV3 plays a role in conditions like skin cancer and immune system diseases. Aberrant expression or mutation of ETV3 correlates with melanoma development where disrupted regulation contributes to abnormal cell proliferation. Its interactions with proteins such as MITF are particularly relevant in melanoma. Additionally ETV3's role in immune modulation can influence autoimmune disorders where dysregulation leads to improper immune activation or repression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853950275753,"sku":"ab176717","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab176717","provider":"Iright","version":"1.0","type":"link"}