{"product_id":"abcam-ab177146","title":"Abcam, ab177146, Anti-Sbf1 antibody [EPR12566]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Sbf1 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12566,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSbf1 also known as SET-binding factor 1 mechanistically acts as a pseudophosphatase due to having a phosphatase sequence motif but lacking phosphatase activity. Sbf1 with a molecular weight of approximately 206 kDa is expressed in various tissues including the brain and the immune system. It belongs to a protein family associated with cellular regulation and its pseudophosphatase domain is significant for its interactions with other proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSbf1 contributes to cellular regulation and signaling pathways. It is known for its involvement in regulating cell growth and migration. Sbf1 does not act alone often forming complexes with other proteins that modulate its function. Researchers have noted its role in cellular structures involved in maintaining the cytoskeleton and intercellular connections which further implicates it in essential cellular processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nSbf1 interacts within the mTOR signaling pathway a critical pathway for regulating cell growth and metabolism. It also plays a role in the PI3K\/AKT pathway important for controlling various cellular processes including proliferation and survival. Through these pathways Sbf1 interacts with proteins such as mTOR and AKT contributing to maintaining cellular functions related to growth signals and nutrient sensing.\u003cbr\u003e\nSbf1 connects to cancer and neurological disorders. Mutations or altered expressions in Sbf1 have been observed in certain types of cancer including breast cancer where it can affect cellular proliferation and survival. Additionally its association with proteins involved in neurological processes suggests a potential link to neurodegenerative disorders. Proteins such as mTOR in cancer and AKT in neurological disorders provide direct connections to Sbf1 highlighting its role in pathways related to these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850346942633,"sku":"ab177146","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab177146","provider":"Iright","version":"1.0","type":"link"}