{"product_id":"abcam-ab177950","title":"Abcam, ab177950, Anti-DDX27 antibody [EPR13147]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal DDX27 antibody. Suitable for ICC\/IF, WB and reacts with Human, Mouse, Rat samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13147,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDDX27 also known as DEAD-box protein 27 operates as an important RNA helicase involved in the unwinding of RNA structures. This protein with a molecular weight of approximately 85 kDa belongs to the DEAD-box family characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). It is ubiquitously expressed in various tissues prominently in the nucleolus where it functions in ribosomal RNA (rRNA) biogenesis and assembly.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDEAD-box protein 27 participates in ribosome biogenesis and interacts with the pre-rRNA processing complexes. This protein acts as an ATP-dependent helicase contributing to the modification and processing of rRNA during ribosome assembly. It often associates with several nucleolar proteins forming a part of multi-protein complexes essential for the synthesis and maturation of ribosomal subunits.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe role of DDX27 integrates mainly within the ribosome biogenesis and RNA processing pathways. It interacts with other DEAD-box proteins such as DDX18 and DDX56 which collaborate in modulating ribosomal RNA processing and ribosome assembly. These pathways are critical for maintaining proper cell proliferation and protein synthesis highlighting its functional importance in cellular processes.\u003cbr\u003e\nDysregulation of DDX27 is linked to certain cancers including colorectal and hepatocellular carcinoma. Aberrations in the expression of DDX27 can affect tumor progression and cellular growth through its influence on ribosome biogenesis. Additionally involvement with proteins like MYC has been observed as MYC-driven regulation of ribosomal biogenesis highlights a potential connection between DDX27 activity and oncogenic pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850308538537,"sku":"ab177950","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab177950","provider":"Iright","version":"1.0","type":"link"}