{"product_id":"abcam-ab177957","title":"Abcam, ab177957, Anti-hnRNP M1-M4 antibody [EPR13509(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HNRPM antibody. Suitable for IHC-P, WB, ICC\/IF, Flow Cyt (Intra) and reacts with Mouse, Rat, Human samples. Cited in 7 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13509(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHeterogeneous nuclear ribonucleoproteins M1-M4 often referred to as hnRNP M or hnRNPM are components of a family of RNA-binding proteins. These proteins have a molecular mass of approximately 77 kDa. They localize primarily in the nucleus but can shuttle between the nucleus and cytoplasm. hnRNP M plays a critical role in mRNA processing including splicing and transport. These proteins are ubiquitously expressed in many tissues highlighting their significance in numerous cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHnRNP M1-M4 are integral to RNA metabolism and the post-transcriptional regulation of gene expression. They participate in the spliceosome complex and influence alternative splicing events by interacting with pre-mRNA. Their binding activity modulates exon inclusion or exclusion contributing to the diversity of the proteome. hnRNP M also interacts with other RNA-binding proteins facilitating various RNA processing events.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe activities of hnRNP M1-M4 intersect significantly with the RNA splicing machinery and mRNA transport pathways. They are integral to the spliceosome pathway and are known to interact with other splicing factors such as serine\/arginine-rich proteins. This interaction is central to the regulation of alternative splicing. hnRNP M also influences the mRNA surveillance pathway ensuring proper mRNA maturation before export to the cytoplasm.\u003cbr\u003e\nHnRNP M1-M4 are associated with cancer and neurodegenerative diseases. Aberrations in hnRNP M expression or function can lead to altered splicing patterns fostering oncogenic processes. Furthermore changes in their activity have been observed in conditions like Alzheimer's disease where they may interact with tau protein and contribute to pathogenesis by affecting tau mRNA splicing. Understanding their role in these contexts provides insights into the mechanisms underpinning these diseases and informs potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844145729705,"sku":"ab177957","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab177957","provider":"Iright","version":"1.0","type":"link"}