{"product_id":"abcam-ab178406","title":"Abcam, ab178406, Anti-GALT antibody [EPR12555]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal GALT antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 8 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12555,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGALT also known as galactose-1-phosphate uridyltransferase is an enzyme involved in the Leloir pathway of galactose metabolism. The GALT protein facilitates the conversion of galactose-1-phosphate (Gal-1-P) and UDP-glucose to UDP-galactose and glucose-1-phosphate important steps in the cellular utilization of galactose. This enzyme has a molecular mass of approximately 43 kDa. GALT is expressed in various tissues and is notably present in the liver and erythrocytes where efficient galactose metabolism is essential.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGALT plays a role in carbohydrate metabolism by regulating galactose conversion to glucose a principal energy source. It does not form part of a complex but works alongside other enzymes such as galactokinase and UDP-galactose 4'-epimerase in the Leloir pathway. This enzymatic action ensures that galactose from food sources is metabolized properly contributing to overall energy homeostasis within the body.\u003cbr\u003e\nPathways\u003cbr\u003e\nGALT participates in the Leloir pathway which is essential for the breakdown and utilization of galactose. Through this pathway GALT interacts indirectly with related proteins like galactokinase and UDP-galactose 4'-epimerase. This enzymatic pathway is linked to complex carbohydrate metabolism and feeds into broader glucose metabolism processes underlining its importance in maintaining glucose levels.\u003cbr\u003e\nGALT is linked to classic galactosemia a rare genetic metabolic disorder. This condition arises from an impairment in the GALT enzyme leading to toxic accumulation of galactose-1-phosphate in the body. Individuals with classic galactosemia often experience symptoms like jaundice liver enlargement and can develop cataracts or mental developmental issues if not treated early. In the context of this disorder proteins such as galactokinase also play a role since they are upstream in the metabolic pathway that leads to the problematic accumulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850243854505,"sku":"ab178406","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab178406","provider":"Iright","version":"1.0","type":"link"}