{"product_id":"abcam-ab178867","title":"Abcam, ab178867, Anti-p38 (phospho T180) antibody [EPR16587]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal MK14 phospho T180 antibody. Suitable for I-ELISA, Dot, WB, Flow Cyt (Intra), IHC-P and reacts with Synthetic peptide - Human, Human samples. Cited in 123 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR16587,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, Dot, I-ELISA, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:ab178867 recognizes alpha, beta, gamma and delta isoforms of (T180) phospho p38. ab178867 weakly cross-reacts with phosphorylated Y182.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nP38 also known as MAPK14 is a member of the mitogen-activated protein kinase (MAPK) family. It functions by phosphorylating various downstream substrates and plays a role in cellular responses. The molecular weight of p38 is approximately 38 kDa. This protein is widely expressed across many tissues including heart brain and lungs. Its activation by stimuli such as cytokines and stress factors helps regulate inflammation and cell cycle control.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nP38 is involved in several cellular processes such as inflammation cell differentiation and apoptosis. It often functions as part of a MAPK signaling complex where it serves a critical role in transmitting signals from the cell surface to the nucleus. It interacts with upstream kinases for activation and affects cellular responses by phosphorylating transcription factors and other protein kinases. Through experiments using techniques like p38 western blot and alpha ELISA scientists can monitor its activity and understand its role in cellular physiology.\u003cbr\u003e\nPathways\u003cbr\u003e\nP38 signaling is integral to both the MAPK and NF-kB pathways. It helps mediate several cellular responses including inflammation and stress responses. Within these pathways p38 interacts with other proteins such as JNK and ERK which helps regulate adaptive and innate immune responses. These interactions ensure distinct yet overlapping signaling responses necessary for cellular homeostasis.\u003cbr\u003e\nP38 plays a role in conditions such as rheumatoid arthritis and cancer. In rheumatoid arthritis p38 contributes to inflammatory processes promoting the production of pro-inflammatory cytokines. In cancer its role varies; while sometimes promoting cancer cell apoptosis it may also aid in tumor survival and proliferation. The protein TNF-alpha often connects indirectly with p38 through inflammatory pathways highlighting its involvement in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844054864041,"sku":"ab178867","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab178867","provider":"Iright","version":"1.0","type":"link"}