{"product_id":"abcam-ab179452","title":"Abcam, ab179452, Anti-ZNFX1 antibody [EPR12330]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ZNFX1 antibody. Suitable for WB and reacts with Human samples. Cited in 8 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12330,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe zinc finger NFX1-type containing 1 (ZNFX1) protein is a DNA-binding protein involved in nucleic acid sensing and immune regulation. It is also known as ZNF-X1. ZNFX1 has a mass of approximately 119 kDa. It expresses in various tissues with notably higher expression levels in the spleen lymph nodes and blood cells. The protein features zinc finger domains which facilitate its interaction with nucleic acids enabling ZNFX1 to play a role in transcriptional regulation and the antiviral response.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZNFX1 influences immune function and viral defense mechanisms. Acting within ribonucleoprotein complexes it participates in the sensing of double-stranded RNA an indicator of viral infection. ZNFX1 helps modulate type I interferon responses a critical aspect of host defense. In these processes it interacts with other proteins necessary for the immune system contributing to maintaining cellular immune surveillance and controlling viral replication.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe actions of ZNFX1 integrate into pathways related to RNA processing and immune responses. Specifically ZNFX1 is involved in the RIG-I-like receptor (RLR) pathway which is important for antiviral responses. In this pathway ZNFX1 interacts with proteins like RIG-I and MAVS to facilitate the proper functioning of antiviral signaling cascades. This pathway's coordination leads to the activation of transcription factors that promote the expression of type I interferons and other cytokines essential for antiviral immunity.\u003cbr\u003e\nZNFX1 associates with immunological conditions including systemic lupus erythematosus (SLE). Abnormalities in ZNFX1 function or expression may contribute to the dysregulation of immune response observed in this autoimmune disease. Furthermore ZNFX1 connects with proteins such as TREX1 known to be involved in the pathogenesis of SLE through the management of immune signaling and prevention of excessive immune activation. Understanding these relationships highlights the significance of ZNFX1 in both normal and disease states of the immune system.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850204729513,"sku":"ab179452","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab179452","provider":"Iright","version":"1.0","type":"link"}