{"product_id":"abcam-ab179833","title":"Abcam, ab179833, Anti-FAM98B antibody [EPR12872]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal FAM98B antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR12872,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFAM98B also known as 'family with sequence similarity 98 member B' is a protein with an approximate mass of 55 kDa. It shows expression in several human tissues with notable levels in the brain liver and lungs. Mechanically FAM98B binds RNA and potentially acts as a scaffold for other protein interactions suggesting roles in RNA processing or regulation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFAM98B takes part in various cellular processes including the assembly of RNA-protein complexes. It associates with the CCR4-NOT complex a critical regulator of mRNA deadenylation and decay. Through these interactions FAM98B possibly influences mRNA stability and gene expression impacting cell growth and differentiation.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers have linked FAM98B to pathways like mRNA surveillance and cell cycle regulation. It interacts with proteins such as CNOT1 and other components of the CCR4-NOT complex. This association plays a role in monitoring mRNA integrity and the promotion of mRNA decay affecting cell proliferation and response to stress.\u003cbr\u003e\nAlterations in FAM98B expression or function relate to cancer and neurodegenerative disease. In cancer abnormal levels of FAM98B might influence tumor growth by interacting with proteins like DDX20 affecting cell cycle regulation. In neurodegenerative disorders disruptions in pathways involving FAM98B could impact neuronal function possibly interacting with proteins within the CCR4-NOT complex to influence cognitive outcomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850390261929,"sku":"ab179833","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab179833","provider":"Iright","version":"1.0","type":"link"}