{"product_id":"abcam-ab180130","title":"Abcam, ab180130, Anti-RNF21\/IFP1 antibody [EPR11305(2)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal RNF21\/IFP1 antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR11305(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRNF21 also known as IFP1 is a human protein with a molecular weight of approximately 43 kDa. It belongs to the RING finger protein family functioning as an E3 ubiquitin ligase. Members of this family typically regulate protein degradation through the ubiquitin-proteasome system. RNF21 is widely expressed in various tissues including the brain liver and heart. This expression suggests important roles across different physiological contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe E3 ubiquitin ligase activity of RNF21 contributes to the regulation of protein homeostasis. RNF21 potentially participates in forming larger protein complexes which could be involved in cellular processes like cell cycle regulation. By tagging specific proteins for degradation RNF21 maintains cellular protein equilibrium. This process impacts various cellular functions including signal transduction and cellular stress responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of RNF21 integrates within the ubiquitin-proteasome pathway and connects to protein turnover. This pathway involves numerous proteins such as ubiquitin-conjugating enzymes which work alongside RNF21. Additionally RNF21 may intersect with signaling pathways related to protein stability where it collaborates with proteins like SCF complexes which also function in protein degradation.\u003cbr\u003e\nRNF21 has connections to neurodegenerative diseases such as Alzheimer's disease where protein aggregation becomes problematic. Aberrant protein degradation can exacerbate these disease conditions. RNF21's interactions with proteins like tau which is involved in Alzheimer's pathology illustrate its potential influence. Moreover its role in inflammatory responses might link RNF21 to disorders like rheumatoid arthritis where improper protein regulation plays a role.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848560234665,"sku":"ab180130","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab180130","provider":"Iright","version":"1.0","type":"link"}