{"product_id":"abcam-ab180149","title":"Abcam, ab180149, Anti-ATP5G1\/G2\/G3 antibody [EPR13908]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal ATP synthase C antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 22 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13908,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nATP5G1 ATP5G2 and ATP5G3 also known as subunits c of the mitochondrial ATP synthase are integral components of the F0 membrane sector of ATP synthase. These proteins have a mass of approximately 8.2 kilodaltons and play an important role in the proton-conducting pore of the enzyme. Expression occurs mainly in tissues with high energy demands such as cardiac and skeletal muscles. As integral membrane proteins they anchor as oligomers in the inner mitochondrial membrane and participate in the process of ATP production.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nATP5G1 ATP5G2 and ATP5G3 form part of the ATP synthase complex which is essential for oxidative phosphorylation and cellular energy production. The ATP synthase complex consists of two main parts: F1 and F0. The subunits c encoded by ATP5G1 ATP5G2 and ATP5G3 construct a rotary motor within the F0 complex that allows proton translocation across the inner mitochondrial membrane. This process facilitates the production of ATP from ADP and inorganic phosphate which is the primary energy currency of the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nATP5G1 ATP5G2 and ATP5G3 subunits participate in the oxidative phosphorylation pathway an important component of cellular respiration. This pathway plays a major role in energy generation by creating ATP through electron transport and chemiosmotic coupling mechanisms. The ATP synthase complex works in conjunction with other proteins like cytochrome c oxidase in the electron transport chain. Efficient functioning of these proteins ensures ATP production which is vital for various cellular processes.\u003cbr\u003e\nDefects or malfunctions in ATP5G1 ATP5G2 and ATP5G3 have associations with mitochondrial disorders and neuromuscular diseases. Dysfunction in the ATP synthase complex can lead to conditions such as Leigh syndrome and other mitochondrial encephalomyopathies. The subunits are also connected with proteins involved in these disorders including the adenine nucleotide translocase. Understanding these relationships helps in diagnosing and developing therapeutic strategies for these energy deficiency-related conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850247426217,"sku":"ab180149","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab180149","provider":"Iright","version":"1.0","type":"link"}