{"product_id":"abcam-ab180181","title":"Abcam, ab180181, Anti-XAB2 antibody [EPR8971]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal XAB2 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR8971,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe XAB2 protein also known as XPA-binding protein 2 is a multi-functional protein involved in several cellular processes. It has a molecular mass of approximately 98 kDa. XAB2 locates in both the nucleus and the cytoplasm of cells indicating its involvement in processes across different cellular compartments. The expression of XAB2 is observed in various tissues suggesting its role in several biological functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nXAB2 participates in several critical processes including transcription splicing and DNA repair. It is a component of the transcription-coupled repair (TCR) machinery and plays a role in the pre-mRNA splicing process. XAB2 is part of a multiprotein complex that includes other important proteins such as the transcription factor IIH (TFIIH) and the excision repair cross-complementation group 2 (ERCC2). This complex ensures accuracy and efficiency in both gene expression and DNA repair processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nXAB2 plays a significant role in the nucleotide excision repair (NER) and RNA splicing pathways. It interacts with proteins like ERCC3 and ERCC2 which are also important for NER. These pathways are essential for maintaining genomic stability by repairing DNA lesions and ensuring proper mRNA processing. XAB2's involvement in these pathways highlights its importance in safeguarding genomic integrity and accurate gene expression.\u003cbr\u003e\nAlterations in XAB2 function relate to conditions such as cancer and Cockayne syndrome. Dysfunction in NER pathways where XAB2 plays a role can lead to genomic instability contributing to the development of various cancers. In Cockayne syndrome mutations in proteins related to the NER pathway like ERCC6 highlight the connection between DNA repair deficiencies and neurodegenerative disorders. Understanding XAB2's role offers insights into these complex diseases and could help in developing therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850420080809,"sku":"ab180181","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab180181","provider":"Iright","version":"1.0","type":"link"}