{"product_id":"abcam-ab181004","title":"Abcam, ab181004, Anti-FHIT antibody - C-terminal","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal FHIT antibody. C-terminal. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Bis(5'-adenosyl)-triphosphatase.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human Bis(5'-adenosyl)-triphosphatase. The exact immunogen used to generate this antibody is proprietary information.P49789\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe 'FHIT' protein also known as the Fragile Histidine Triad protein weighs about 16.8 kDa. It is a tumor suppressor and is widely expressed in various tissues including the lungs kidneys and pancreas. FHIT is encoded by the FHIT gene located on chromosome 3 specifically at a common fragile site. The protein plays an important role in maintaining genomic integrity and preventing tumorigenesis. It acts as a diadenosine triphosphate hydrolase breaking down dinucleoside polyphosphates.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe FHIT protein interacts with other cellular proteins to regulate apoptosis and cell proliferation. It is part of several molecular complexes that are involved in cellular stress responses. The FHIT protein binds to other proteins to initiate a cascade of events leading to programmed cell death in cells with damaged DNA. This role is critical because it prevents the development of cancer by eliminating potentially malignant cells before they proliferate.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe FHIT protein participates in the DNA damage response and apoptotic pathways. It is related to the p53 signaling pathway a major pathway controlling cell cycle arrest and apoptosis. FHIT is thought to modulate p53 activity promoting apoptosis in response to genotoxic stress. It also synergizes with proteins like PTEN to enhance protective responses against DNA damage helping to regulate cell survival and proliferation.\u003cbr\u003e\nThe FHIT protein has significant implications for cancer particularly lung and esophageal cancers. Studies show that loss of FHIT expression correlates with tumor progression and a poor prognosis in these cancers. The protein's inactivation often pairs with mutations in proteins like p53 which further disrupts cell cycle control and enhances malignant transformation. FHIT serves as a marker for early detection and a potential target for therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850079916201,"sku":"ab181004","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab181004","provider":"Iright","version":"1.0","type":"link"}