{"product_id":"abcam-ab181033","title":"Abcam, ab181033, Anti-EIF2B5 antibody [EPR13533]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal EIF2B5 antibody. Suitable for ICC\/IF, WB, IHC-P and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13533,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEIF2B5 also known as eukaryotic translation initiation factor 2B subunit epsilon plays an important role in the regulation of protein synthesis. It is a catalytic subunit of the larger eIF2B complex which is responsible for guanine nucleotide exchange on eIF2. This protein has a molecular mass of approximately 85 kDa. EIF2B5 is ubiquitously expressed indicating its importance in various tissues. Its role in translation initiation is fundamental in controlling cellular responses to stress and nutrient signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProtein synthesis control by eIF2B5 impacts cell growth and adaptation. As an important component of the eIF2B complex which consists of five different subunits EIF2B5 directly interacts with eIF2 to facilitate GDP-GTP exchange. This process is essential for recycling eIF2 for successive rounds of translation initiation. Proper function of the eIF2B complex ensures cellular capacity to manage stress conditions such as amino acid deprivation or viral infection by modulating protein synthesis rates to conserve resources and adapt.\u003cbr\u003e\nPathways\u003cbr\u003e\nEIF2B5 plays a significant role in the integrated stress response (ISR) pathway. Through its involvement in ISR it links with proteins like eIF2 and integrates signaling from different stressors. This pathway helps in adjusting the translation of specific mRNAs by phosphorylating eIF2 making EIF2B5 essential for the regulation of global and gene-specific translation. Additionally dysfunctions in its regulation may impact the mTOR pathway an important regulator of cell growth in response to nutrient availability although EIF2B5 mainly functions in ISR.\u003cbr\u003e\nMutations in EIF2B5 are associated with leukoencephalopathy with vanishing white matter (VWM) a rare neurological disorder. This condition links EIF2B5 dysfunction to impaired oligodendrocyte maturation and myelination in the brain. Additionally altered functioning of EIF2B5 may relate to other stress-related disorders as its regulatory role in translation impacts cell survival under stress conditions. Connections between eIF2B5 and proteins like eIF2 underline its involvement in proper neuronal function and response to metabolic changes important to understanding disorders like VWM.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850369421481,"sku":"ab181033","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab181033","provider":"Iright","version":"1.0","type":"link"}