{"product_id":"abcam-ab181040","title":"Abcam, ab181040, Anti-MBIP antibody [EPR13952]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal MBIP antibody. Suitable for IP, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13952,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMBIP also known as Mps-One Binder kinase activator-like protein 1 acts mechanically by being a component of certain cellular complexes involved in intracellular signaling. It has a molecular mass of approximately 25 kDa. Expression of MBIP occurs in many tissues but it is found at higher levels in brain and kidney tissues suggesting its significant role in these areas.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMBIP regulates signaling pathways that control cell growth development and differentiation. As a part of the c-Jun N-terminal kinase (JNK) signalosome complex MBIP influences pathways that mediate responses to stress and inflammatory stimuli. The presence of MBIP in these complexes emphasizes its role in modulating the cellular response to environmental changes shedding light on how it contributes to maintaining cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nMBIP functions within the JNK signaling and the domino effect on MAP kinase pathways. In the JNK pathway MBIP interacts closely with proteins such as MKK4 and JNKs to ensure proper signal transduction and cellular outcomes. Its activity helps mediate cellular responses modulating processes like apoptosis and cell survival indicating its importance in maintaining cellular balance and health.\u003cbr\u003e\nMBIP shows relevance to conditions like cancer and neurodegenerative diseases. Aberrant MBIP expression or activity can disrupt the JNK pathway leading to uncontrolled cell proliferation in cancer or altered neuronal functioning in conditions like Alzheimer's disease. Connections between MBIP and other proteins such as JNKs and MKK4 highlight its influence on pathological developments in these disorders providing a critical link between cellular signaling and disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850407465129,"sku":"ab181040","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab181040","provider":"Iright","version":"1.0","type":"link"}