{"product_id":"abcam-ab181047","title":"Abcam, ab181047, Anti-MMS22L (C6ORF167) antibody [EPR13654]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal MMS22L (C6ORF167) antibody. Suitable for IP, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13654,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Rat, Mouse,\u003cbr\u003e\nApplications:IP, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMMS22L (C6ORF167) is a protein that plays a significant role in DNA damage response and repair. It is also known as a part of a protein complex that ensures genomic stability. MMS22L has a mass of approximately 51 kDa and is found expressed in various tissues notably in those with proliferative capacity such as testis and thymus. This protein becomes active upon DNA replication stress and enhances the stabilization of replication forks.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMMS22L associates with several other proteins to form the MMS22L-TONSL complex which is critical for repairing DNA double-strand breaks. This complex facilitates homologous recombination repair by assisting in the recruitment of important repair factors. Through its functionality MMS22L plays a critical part in maintaining genomic stability ensuring that cells replicate accurately and efficiently.\u003cbr\u003e\nPathways\u003cbr\u003e\nMMS22L integrates into the homologous recombination repair pathway and the Fanconi anemia pathway. In its activities it collaborates with proteins like TONSL and RAD51 which are central in maintaining the integrity of DNA through accurate repair. These pathways highlight MMS22L’s involvement in repairing DNA damages particularly during the S and G2 phases of the cell cycle.\u003cbr\u003e\nMMS22L has connections to conditions like cancer and Fanconi anemia where genomic instability is a common feature. Dysregulation or mutations affecting MMS22L can impede DNA repair mechanisms thereby contributing to the development of these disorders. In cancer MMS22L's role connects with proteins like BRCA2 highlighting its importance in pathways that when disrupted lead to tumor development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844212412585,"sku":"ab181047","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab181047","provider":"Iright","version":"1.0","type":"link"}