{"product_id":"abcam-ab181253","title":"Abcam, ab181253, Anti-OP-2 antibody [EPR13357]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal OP-2 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13357,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody detects dominant ~35kDa extra band in some samples, e.g. WI-38 and SK-OV-3.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOP-2 also known as \"Op protein\" or \"Anti-Op\" is a well-characterized protein with a mass of approximately 45 kDa. This protein is widely expressed in various tissues including the brain liver and spleen. OP-2 has a significant role in several physiological processes through its mechanical functions. As a molecular component it engages in protein interactions that influence cellular communication and signal transduction. Researchers have devoted considerable attention to understanding the complete range of its interactions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein participates in essential regulatory networks and modulates cellular responses to external stimuli. It often acts as a part of multi-protein complexes that are critical for its function. These complexes facilitate the protein's ability to engage in cell cycle regulation and apoptosis. Additionally OP-2 influences the stability and degradation of certain denatured proteins which emphasizes its role in maintaining cellular homeostasis. The protein's significance extends to acting as a mediator in immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nOP-2 plays important roles in both the MAPK\/ERK and NF-kB signaling pathways. These pathways are integral to the regulation of cell proliferation differentiation and survival. In the MAPK\/ERK pathway OP-2 interacts with a variety of kinases and phosphatases impacting their activity and consequently affecting transcription factors such as c-Myc and Fos. Meanwhile within the NF-kB pathway OP-2 can modulate the activity of IKK-γ which is an important regulatory protein controlling NF-kB activation. Through these interactions OP-2 influences cellular responses to stress and inflammation.\u003cbr\u003e\nOP-2 shows a strong connection to certain cancers and autoimmune diseases. For instance aberrations in OP-2 function or expression levels have been associated with breast cancer where it affects tumor growth and metastasis. Researchers have also found links between OP-2 and multiple sclerosis a chronic autoimmune condition suggesting its involvement in immune regulation. Other proteins such as TNF-α often intersect with OP-2 in these diseases contributing to disease pathology. Understanding these associations helps in identifying potential therapeutic targets for intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850436432041,"sku":"ab181253","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab181253","provider":"Iright","version":"1.0","type":"link"}