{"product_id":"abcam-ab181560","title":"Abcam, ab181560, Anti-Pan Trk antibody [EPR17341]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nAnti-Pan Trk antibody [EPR17341] (ab181560) is a rabbit monoclonal antibody detecting Pan Trk in  Western Blot, IHC-P, ICC\/IF . Suitable for  Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 30 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR17341,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nAnti-Pan Trk antibody [EPR17341] (ab181560) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC\/IF, IHC-P and WB.\u003cbr\u003e\nAbcam's high quality manufacturing and validation processes ensure Anti-Pan Trk antibody [EPR17341] (ab181560) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.\u003cbr\u003e\nAnti-Pan Trk antibody [EPR17341] (ab181560) specifically detects Pan Trk (UniProt ID: Q16620; Molecular weight: 89kDa) and is sold in 100 µL and 1 mL selling sizes.\u003cbr\u003e\nConjugation-ready, carrier free format available for antibody clone EPR17341 -\u003cbr\u003e\nab218577\u003cbr\u003e\nAntibody clone EPR17341 is also available pre-conjugated to a variety of labels for your convenience - HRP, Biotin, Alexa Fluor\u003cbr\u003e\n488, Alexa Fluor\u003cbr\u003e\n647, Alexa Fluor\u003cbr\u003e\n594, Alexa Fluor\u003cbr\u003e\n568, Alexa Fluor\u003cbr\u003e\n555, Alexa Fluor\u003cbr\u003e\nab209465\u003cbr\u003e\nab252166\u003cbr\u003e\nab308600\u003cbr\u003e\nab311129\u003cbr\u003e\nab311762\u003cbr\u003e\nab313042\u003cbr\u003e\nab313243\u003cbr\u003e\nab321255\u003cbr\u003e\nEnhanced validation in multi normal and malignant Tissue Microarrays. TRK is a key target for investigating neurotrophic receptors and signal transduction. It plays a crucial role in cancer therapy research, particularly in understanding NTRK gene fusions and their implications. TRK is widely analysed in studies of TRK inhibitors and neuroblastoma. Mutations and alterations in TRK are linked to various cancers, making it a significant target for developing targeted cancer therapies.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPan Trk also known as tropomyosin receptor kinase (Trk) includes three different receptors: TrkA TrkB and TrkC. These belong to the neurotrophic tyrosine receptor kinase (NTRK) family each with a mass of roughly 140 kDa. They are mainly expressed in neuronal tissues but can also appear in non-neuronal tissues. The pan Trk term refers to antibodies that detect all three receptors simultaneously. These receptors play an important role in the cellular response to neurotrophins which are essential for differentiation survival and plasticity of neurons.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Trk receptors bind with neurotrophins such as nerve growth factor (NGF) brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) to initiate signaling that supports neuronal survival and growth. These receptors function as part of a larger receptor-ligand complex. Upon neurotrophin binding the Trk receptors undergo dimerization and transphosphorylation triggering downstream signaling cascades. This activation modulates cellular processes including synaptic strength enhancement and neuronal network formation.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe Trk receptors activate important cellular signaling pathways such as the PI3K\/AKT and MAPK\/ERK pathways. These pathways regulate cell survival proliferation and differentiation. The Trk receptors interact with proteins like Shc PLCγ and Grb2 which facilitate signal transduction to multiple downstream effectors. This integration into signaling networks allows cross-talk with other signaling molecules and pathways orchestrating complex biological functions.\u003cbr\u003e\nPan Trk expression links to conditions like neurodegenerative diseases and certain cancers. Overexpression or mutation of Trk receptors can lead to oncogenesis particularly in tumor types like gliomas and neuroblastomas. Moreover abnormal Trk signaling has associations with Alzheimer's disease where dysregulated nerve growth factor signaling contributes to neurodegeneration. Targeted therapies and pan Trk inhibitors offer potential treatment strategies for these diseases by modulating receptor activity and correcting signaling pathway imbalances.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844065546409,"sku":"ab181560","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab181560","provider":"Iright","version":"1.0","type":"link"}