{"product_id":"abcam-ab181984","title":"Abcam, ab181984, Anti-TADA3L antibody [EPR13864]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal TADA3L antibody. Suitable for WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR13864,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTADA3L also known as Transcriptional Adaptor 3-Like is part of the larger transcriptional coactivator complexes. The protein has a mass of approximately 55 kDa and is expressed in various tissues including liver and kidney. Mechanically TADA3L acts as a transcriptional adaptor interacting with DNA-binding transcription factors and assisting the recruitment of additional coactivators necessary for gene transcription.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein assists in regulating gene expression by serving as a component of the human Ada-Two-A containing (hATAC) complex. The hATAC complex which includes TADA3L plays a role in histone acetylation allowing chromatin to be more accessible for transcriptional machinery. TADA3L's involvement in this complex underlines its role in modulating transcription and influencing cell cycle and proliferation processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe TADA3L protein integrates into networks influencing transcriptional regulation and chromatin remodeling pathways. It associates with GCN5 and PCAF which are critical for histone acetyl transferase (HAT) activity within these pathways. Through its interaction with these proteins TADA3L contributes to the control of gene expression and is an important part of maintaining homeostasis in cellular function.\u003cbr\u003e\nAlterations in TADA3L function or expression link to cancer and developmental disorders. Mutations or deregulation of this protein can disrupt normal transcriptional regulation leading to oncogenesis. In cancer pathways TADA3L shows connections with proteins like p53 a widely studied tumor suppressor where its impairment could affect apoptotic and cell cycle arrest pathways contributing to tumor development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850439741609,"sku":"ab181984","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab181984","provider":"Iright","version":"1.0","type":"link"}