{"product_id":"abcam-ab183045","title":"Abcam, ab183045, Anti-FAF1 antibody [EPR14754]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal FAF1 antibody. Suitable for IP, WB, ICC\/IF, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14754,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, Flow Cyt (Intra), ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFAF1 also known as FAS-associated factor 1 functions mechanically by interacting with the FAS receptor to modulate apoptotic processes. It has a molecular weight of approximately 74 kDa. This protein can be found in various tissues with higher expression in the brain liver and kidney. The expression suggests its diverse roles in cellular processes across different organ systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFAF1 interacts with ubiquitin-like modifiers to influence the cellular response to stress. It is part of the death-inducing signaling complex (DISC) where it contributes to the regulation of apoptosis. In addition to apoptosis FAF1 plays a role in regulating protein degradation processes connecting its function to proteostasis in cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nFAF1 takes part in significant cellular processes including the apoptotic signaling pathway and the NF-kB signaling pathway. In these pathways it interacts with FAS and NF-kB proteins contributing to cell death and inflammatory responses respectively. The influence on these pathways showcases its role in maintaining balance between cell survival and cell death.\u003cbr\u003e\nFAF1 displays connections to neurodegenerative diseases and cancers. It has been implicated in the pathogenesis of Parkinson's disease where its dysregulation can affect neuronal survival. Furthermore its interaction with FAS in the apoptosis pathway links FAF1 to certain types of cancers where apoptotic failure results in uncontrolled cell growth. Understanding FAF1's role is essential for developing therapeutic strategies targeting these pathways and associated conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850288320681,"sku":"ab183045","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab183045","provider":"Iright","version":"1.0","type":"link"}