{"product_id":"abcam-ab183512","title":"Abcam, ab183512, Anti-Plakophilin 1 antibody [EPR14890]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Plakophilin 1 antibody. Suitable for WB, ICC\/IF, Flow Cyt (Intra) and reacts with Mouse, Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14890,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPlakophilin 1 also known as PKP1 is an important component of the cell's structural and signaling machinery. It is a member of the arm-repeat family of proteins and has a molecular mass of around 83 kDa. Plakophilin 1 is expressed in various epithelial tissues where it plays an important role in stabilizing cell junctions. It localizes mainly to desmosomes which are adhesive structures that connect cells together maintaining tissue integrity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein is a core part of desmosomal plaques which are thickened structures on the inner surface of cell membranes where desmosomes attach. Plakophilin 1 assists in linking the cadherin-catenin complex to intermediate filaments in the cytoskeleton promoting cell-cell adhesion. It is part of a larger protein complex that ensures mechanical strength and resilience across epithelial layers.\u003cbr\u003e\nPathways\u003cbr\u003e\nPlakophilin 1 is involved in the assembly and organization of desmosomal junctions which are part of the broader adherens junction pathway. It interacts with several key proteins including desmoplakin and plakoglobin contributing to the stability and function of cell adhesions. These interactions are essential for maintaining the structural integrity and signaling capabilities of epithelial tissues.\u003cbr\u003e\nPlakophilin 1 mutations have been linked to ectodermal dysplasia-skin fragility syndrome a condition characterized by compromised skin integrity and hair anomalies. This protein is also associated with certain types of cardiomyopathy due to its role in desmosomal structure and cell adhesion. Its interaction with desmoplakin is particularly relevant in these disorders where faulty cell junctions lead to tissue fragility and pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850330656937,"sku":"ab183512","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab183512","provider":"Iright","version":"1.0","type":"link"}