{"product_id":"abcam-ab184100","title":"Abcam, ab184100, Anti-Clusterin alpha chain antibody [EPR17539-95]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Clusterin antibody. Suitable for IP, WB, IHC-Fr, IHC-P and reacts with Mouse, Rat samples. Cited in 8 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR17539-95,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:IP, WB, IHC-Fr, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nClusterin also called apolipoprotein J has an important role in various biological processes. The clusterin alpha chain which is a segment of the clusterin protein is synthesized as part of a precursor that is then cleaved into alpha and beta chains. The mass of this alpha chain is around 34 kDa. Clusterin is expressed in multiple tissues including the liver brain and testes. It often appears in bodily fluids such as plasma and cerebrospinal fluid.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe clusterin protein operates as a chaperone that prevents non-specific aggregation of proteins which is important in maintaining cellular protein homeostasis. It forms part of a heterodimeric complex composed of alpha and beta chains. This protein also contributes to lipid transport due to its apolipoprotein nature. Its expression levels can increase in response to stress-related conditions suggesting an adaptive function to protect cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nClusterin is involved in the regulation of cell death and survival pathways. It plays a role in the complement cascade providing protective effects against membrane attack complexes. Clusterin interacts with other proteins such as CRP which assists in modulating these pathways and influences inflammation as part of the immune response.\u003cbr\u003e\nDisruption of clusterin expression or function relates to neurodegenerative disorders including Alzheimer's disease. The clusterin protein associates with amyloid-beta affecting its aggregation and clearance. It also connects to prostate cancer where altered expression of clusterin might influence tumor cell survival and treatment resistance. Understanding these interactions might offer potential therapeutic strategies with clusterin acting as a target or biomarker in diagnostics or treatment development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850290516137,"sku":"ab184100","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab184100","provider":"Iright","version":"1.0","type":"link"}