{"product_id":"abcam-ab184164","title":"Abcam, ab184164, Anti-TMEM43 antibody [EPR15378(B)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal TMEM43 antibody. Suitable for WB, IHC-P and reacts with Human, Rat, Mouse samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR15378(B),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTMEM43 also known as LUMA is a transmembrane protein with a mass of approximately 47 kDa. This protein localizes mainly to the nuclear envelope where it plays a structural role in maintaining nuclear integrity. It is widely expressed in various tissues especially in cardiac and skeletal muscle cells. Through its location and structure TMEM43 contributes to the physical and functional stability of the nuclear envelope interacting with other nuclear envelope components.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nResearchers recognize TMEM43 as an important player in the integrity of cellular architectures maintaining nuclear shape and mechanical stability. It forms part of a larger protein complex within the nuclear envelope referred to as the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. The interactions between TMEM43 and other LINC complex proteins contribute to its role in cellular mechanical transduction and nuclear-cytoskeletal coupling essential for cellular responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nTMEM43 plays a significant role in pathways related to nuclear-cytoskeletal interaction and mechanotransduction. It associates with the LINC complex proteins like Emerin and Lamin A\/C facilitating the integration of signals from the cytoskeleton to the nucleus. This involvement places TMEM43 within the context of mechanosensitive pathways important for cellular responses to mechanical stimuli which are relevant in tissue development and homeostasis.\u003cbr\u003e\nTMEM43 links closely to certain cardiac conditions and muscular disorders. Mutations in this protein are known to cause arrhythmogenic right ventricular cardiomyopathy (ARVC) a life-threatening heart disease characterized by fibro-fatty degeneration of the right ventricle. This connection also implicates proteins like Desmoplakin and Plakophilin-2 in ARVC as they form part of the complex that interacts with TMEM43. Additionally TMEM43's dysfunction may relate to muscular disorders where altered interactions with members of the nuclear envelope proteins contribute to muscle weakness and degeneration.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850329411753,"sku":"ab184164","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab184164","provider":"Iright","version":"1.0","type":"link"}