{"product_id":"abcam-ab184169","title":"Abcam, ab184169, Anti-Germinal Center Kinase\/GCK antibody [EPR14304]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Germinal Center Kinase\/GCK antibody. Suitable for WB, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR14304,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGerminal Center Kinase (GCK) also known as GCK kinase or GCK is part of the STE20 family of serine\/threonine protein kinases. It has a mass of approximately 72 kDa. GCK mainly expresses in lymphoid tissues and is important for signaling processes. Its activity involves phosphorylating downstream substrates which helps regulate cell signaling pathways associated with cell survival and apoptosis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis kinase plays a significant role in the body's immune response by participating in signal transduction pathways that govern germinal center formation and function. GCK operates as a kinase that is sometimes part of larger protein complexes which allows it to have diverse biological roles. Through various signaling cascades it influences cellular activities that are important for immune system function including B-cell development and antibody production.\u003cbr\u003e\nPathways\u003cbr\u003e\nGCK integrates itself into major signaling routes such as the MAPK and JNK pathways. These pathways control a range of cellular processes including proliferation differentiation and stress responses. GCK interacts with other proteins like MEKK1 and 14-3-3 which facilitate its role in these pathways. Such interactions enable the regulation of important cellular functions by modifying target proteins through phosphorylation.\u003cbr\u003e\nDysregulated GCK activity has implications in various conditions such as autoimmune diseases and certain types of cancer. Abnormal GCK function may alter immune cell regulation which can result in autoimmune phenomena. Additionally modified GCK signaling impacts cancer progression where its interaction with tumor suppressor proteins like p53 may influence tumorigenesis and tumor survival mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850376663209,"sku":"ab184169","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab184169","provider":"Iright","version":"1.0","type":"link"}