{"product_id":"abcam-ab184267","title":"Abcam, ab184267, Anti-HuD + HuC antibody [EPR19098]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nAnti-HuD + HuC antibody [EPR19098] (ab184267) is a rabbit monoclonal antibody detecting HuC in  Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, IHC-P, IHC-Fr, ICC\/IF, ELISA . Suitable for  Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 10 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR19098,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IF, Flow Cyt (Intra), IHC-Fr, IP, I-ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody shows very weak cross reactivity to HuB in WB test. Please contact our Scientific support team for more information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-HuD + HuC antibody [EPR19098] (ab184267) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunohistochemistry (IHC-Fr), Immunocytochemistry\/immunofluorescence (ICC\/IF), ELISA in Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of HuC?\u003cbr\u003e\nAnti-HuD + HuC [EPR19098] (ab184267) specifically detects a band for HuC (UniProt: Q60900) at a molecular weight of 40kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-HuD + HuC [EPR19098] (ab184267) was first used in a scientific publication in 2017 and has been cited over 10 times in peer-reviewed journals.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe HuD and HuC proteins also known as neuronal ELAV-like RNA binding proteins play critical roles in neuronal development and function. These proteins weigh approximately 37 kDa and are specifically expressed in neurons. They are part of the family of ELAV (Embryonic Lethal Abnormal Vision) proteins with HuD sometimes referred to as C HuD. HuD and HuC are involved in RNA stabilization processes by binding to AU-rich elements in the 3' untranslated regions (3' UTR) of mRNA which influence the regulation of mRNA turnover stability and translation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHuD and HuC proteins are integral to the regulation of gene expression during neuronal differentiation. They participate in RNA processing machinery and can form complexes with other RNA-binding proteins affecting the neuronal mRNA transcriptome. These interactions facilitate the stabilization and localization of mRNAs essential for synaptic plasticity and neuron functionality. Their presence highlights the post-transcriptional regulation mechanisms vital for nervous system development and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nHuD and HuC proteins are essential players in neuron-specific mRNA processing pathways. They interact closely with molecular pathways involved in learning and memory particularly those involving the MAPK\/ERK pathway. They frequently co-regulate mRNA with other proteins like HuR a ubiquitous ELAV protein. These interactions assist in the modulation of gene expression profiles necessary for proper neuronal signaling and plasticity.\u003cbr\u003e\nHuD and HuC proteins are linked with conditions such as neurological cancer and neurodegenerative disorders. Their deregulation has been associated with neuroblastoma where aberrant expression influences tumor proliferation. Additionally alterations in HuD and HuC protein function have connections with Alzheimer's disease wherein their interactions with tau protein impact disease progression. Understanding these associations provides insights into potential therapeutic targets and interventions for such conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844061745321,"sku":"ab184267","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/abcam-ab184267","provider":"Iright","version":"1.0","type":"link"}